Intranasal administration of therapeutic agents is practiced from ancient times, and the route gained more importance as the time passed by for category of drugs showing local action. Now days this route is gaining more importance due to its numerous advantages and has emerged as a Novel Drug Delivery System providing access to the therapeutic agents throughout the human body. Many different formulations for nasal delivery are available in market at present. Among all of these nasal gels are most appealing and promising formulations for systemic delivery of drugs due to the success achieved in overshadowing many different problems related to drug, formulation, or the physiological aspects of human body. Present review covers points related to intranasal delivery such as a brief look at anatomy physiology, factors affecting in detail, mechanism of absorption which have important effects on and contribute to the nasal formulation. Also some of the important aspects of gels such as the microstructure, and the polymers used which should be considered in the nasal gel formulation are included. Together these two aspects work as guideline for the successful formulation.
Loading....